Aerobic training increases the stimulated percentage of CD4+CD25+ in older men but not older women
Broadbent, Suzanne and Gass, Gregory (2008) Aerobic training increases the stimulated percentage of CD4+CD25+ in older men but not older women. European Journal of Applied Physiology, 103 (1). pp. 79-87. ISSN 1439-6319Full text for this resource is not available from the Research Repository.
The purpose of the present study was to determine whether 12 months of moderate intensity cycling would increase the expression of IL-2 (CD25+) receptors in T helper (CD4+) lymphocytes in men and women aged 65– 75 years. Fourteen men and 10 women completed 52 weeks of moderate intensity cycling (60% VO2peak). Subjects trained (TR) three times per week for 45 min per session. Eight age-matched untrained (UT) male and eight UT female subjects acted as controls. Resting blood samples were taken from TR and UT subjects every 4 weeks. Leukocyte concentration was measured using a full blood count. PHA-stimulated CD4+ lymphocytes were analysed for changes in the expression of CD25+, by Xow cytometry. Training signiWcantly increased VO2peak (l min¡1, ml kg¡1 min¡1) in male (+14.3, +16%) and female (+16.7, +27.8%) groups. The TR male group showed a signiWcantly lower percentage of CD4+CD25+ than the male UT in January but the TR male percentage was signiWcantly higher than the UT male group during February, March, April, May, June, September B and December. The female TR group showed a signiWcantly higher percentage CD4+CD25+ than the female UT only during July. There were also signiWcant sequential monthly changes in the percentage of CD4+CD25+ for male and female UT and TR groups. SigniWcant increases in the percentage of CD4+CD25+ in the male TR group suggest training-enhanced lymphocyte mitogenic responsiveness. Moderate intensity long-term training may increase the recruitment of active memory CD4+CD25+ in men rather than women.
|Uncontrolled Keywords:||ResPubID16822. IL-2 • IL-2R, lymphocyte response, moderate intensity training|
|Subjects:||Faculty/School/Research Centre/Department > School of Sport and Exercise Science
FOR Classification > 0606 Physiology
SEO Classification > 970102 Expanding Knowledge in the Physical Sciences
|Date Deposited:||25 Aug 2011 06:32|
|Last Modified:||25 Mar 2013 00:48|
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|Citations in Scopus:||2 - View on Scopus|
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