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Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity

Dass, Crispin R and Friedhuber, Anna M and Khachigian, Levon M and Dunstan, David E and Choong, Peter F. M (2008) Biocompatible chitosan-DNAzyme nanoparticle exhibits enhanced biological activity. Journal of Microencapsulation, 25 (6). pp. 421-425. ISSN 0265-2048

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Abstract

DNAzymes are oligonucleotides capable of specific catalysis of target mRNA. To date, a delivery vehicle for DNAzymes has not been developed. Chitosan is a biomaterial obtained abundantly in nature. A biocompatible c-jun (an oncogene) DNAzyme nanoparticle formulated from chitosan was found to be more active against osteosarcoma (bone cancer) cells, inducing apoptotic cell death in these cells. The formulation was stable in serum for a week and at room temperature for a month. Clinically, knockdown of c-jun gene expression with chitosan nanobiotechnology may improve treatment outcome for tumours growing in bone

Item Type: Article
Uncontrolled Keywords: ResPubID18861. Chitosan, c-jun, apoptosis, deoxyribozyme, nanoparticle, bone cancer cells
Subjects: RFCD Classification > 320000 Medical and Health Sciences
FOR Classification > 1117 Public Health and Health Services
FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
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Depositing User: VUIR
Date Deposited: 15 Sep 2011 01:14
Last Modified: 08 Feb 2015 23:58
URI: http://vuir.vu.edu.au/id/eprint/3596
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Citations in Scopus: 17 - View on Scopus

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