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Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model

Dass, Crispin R and Friedhuber, Anna M and Khachigian, Levon M and Dunstan, David E and Choong, Peter F. M (2008) Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. Cancer Biology and Therapy, 7 (7). pp. 1033-1036. ISSN 1538-4047

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Abstract

c-jun has been found to be upregulated in a variety of cancers including osteosarcoma. DNAzymes are oligonucleotides capable of specific downregulation of target genes. c-jun knockdownmediated apoptosis in osteosarcoma cells involved caspases-1, -2 and -8, but not the Fas/FasL pathway. A c-jun DNAzyme, encapsulated within a novel cationic multilamellar vesicle liposome, inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasising model of the disease. The 60 nm DDAB:DOPE liposome was formulated using ethanol injection/ extrusion. Clinically, downregulation of c-jun may proffer an improved treatment outcome for these tumors originating in bone.

Item Type: Article
Uncontrolled Keywords: ResPubID18860. c-jun, cancer, apoptosis, deoxyribozyme, osteosarcoma, liposome
Subjects: RFCD Classification > 320000 Medical and Health Sciences
FOR Classification > 1117 Public Health and Health Services
FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Depositing User: VUIR
Date Deposited: 15 Sep 2011 01:16
Last Modified: 08 Feb 2015 23:56
URI: http://vuir.vu.edu.au/id/eprint/3597
DOI: 10.4161/cbt.7.7.6037
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Citations in Scopus: 14 - View on Scopus

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