Involvement of c-jun in human liposarcoma growth: supporting data from clinical immunohistochemistry and DNAzyme efficacy
Dass, Crispin R and Galloway, Stuart J and Clark, Jonathan C. M and Khachigian, Levon M and Choong, Peter F. M (2008) Involvement of c-jun in human liposarcoma growth: supporting data from clinical immunohistochemistry and DNAzyme efficacy. Cancer Biology and Therapy, 7 (8). pp. 1297-1301. ISSN 1538-4047Full text for this resource is not available from the Research Repository.
c-jun has been found to be upregulated in a variety of cancers. Recently, this oncogene has also been implicated in liposarcoma (LS) progression. c-jun knockdown mediated by a deoxyribozyme induced apoptosis in LS cells via evoking caspase-10, but not the Fas/FasL pathway. A novel orthotopic model for LS was established in the hindlimb of mice using human cells to extend the evaluation of effects of c-jun knockdown in vivo. Tumor take in vivo was 100%, with growths resembling high grade aggressive LS. The c-jun deoxyribozyme inhibited the growth of LS in this model. Clinically, downregulation of c-jun may proffer an improved treatment outcome for liposarcoma. The new model for LS described here will enable better testing of agents with therapeutic potential against LS.
|Uncontrolled Keywords:||ResPubID18868. c-jun, cancer, apoptosis, deoxyribozyme, liposarcoma, orthotopic, gene therapy|
|Subjects:||RFCD Classification > 320000 Medical and Health Sciences
FOR Classification > 1117 Public Health and Health Services
Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
|Date Deposited:||15 Sep 2011 01:17|
|Last Modified:||10 Mar 2015 06:15|
|ePrint Statistics:||View download statistics for this item|
|Citations in Scopus:||19 - View on Scopus|
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