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c-Jun knockdown sensitizes osteosarcoma to doxorubicin

Dass, Crispin R and Khachigian, Levon M and Choong, Peter F. M (2008) c-Jun knockdown sensitizes osteosarcoma to doxorubicin. Molecular Cancer Therapeutics, 7 (7). pp. 1909-1912. ISSN 1535-7163

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Abstract

The oncogene c-Jun has been found to be up-regulated in a variety of cancers, including osteosarcoma. Doxorubicin is a frontline chemotherapeutic against osteosarcoma, but is limited by toxicity. DNAzymes are oligonucleotides capable of specific catalysis of target mRNA. A biocompatible c-Jun DNAzyme nanoparticle formulated from chitosan regressed the growth and metastasis of preestablished tumors, especially in combination with doxorubicin. In vitro data confirmed that c-Jun knockdown chemosensitized these cells to doxorubicin treatment. c-Jun down-regulation–mediated tumor inhibition also led to concomitant decreased osteolysis. Clinically, knockdown of c-Jun with chitosan nanobiotechnology may proffer an improved treatment outcome for osteosarcoma.

Item Type: Article
Uncontrolled Keywords: ResPubID18862. c-Jun, osteosarcoma, doxorubicin, DNAzymes, tumors, mRNA, chitosan, bone, cancer
Subjects: RFCD Classification > 320000 Medical and Health Sciences
Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1117 Public Health and Health Services
Depositing User: VUIR
Date Deposited: 16 Sep 2011 04:04
Last Modified: 10 Mar 2015 06:16
URI: http://vuir.vu.edu.au/id/eprint/3599
DOI: 10.1158/1535-7163.MCT-08-0086
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Citations in Scopus: 18 - View on Scopus

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