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Sprint training increases muscle oxidative metabolism during high-intensity exercise in patients with type 1 diabetes

Harmer, Alison R and McKenna, Michael J and Chisholm, Donald J and Hunter, Sandra K and Ruell, Patricia A and Naylor, Justine M and Maxwell, Lyndal J and Flack, Jeff R (2008) Sprint training increases muscle oxidative metabolism during high-intensity exercise in patients with type 1 diabetes. Diabetes Care, 31 (11). pp. 2097-2102. ISSN 0149-5992

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Abstract

Objective — To investigate sprint-training effects on muscle metabolism during exercise in subjects with (type 1 diabetic group) and without (control group) type 1 diabetes. Research Design and Methods — Eight subjects with type 1 diabetes and seven control subjects, matched for age, BMI, and maximum oxygen uptake (V˙ O2peak), undertook 7 weeks of sprint training. Pretraining, subjects cycled to exhaustion at 130% V˙ O2peak. Posttraining subjects performed an identical test. Vastus lateralis biopsies at rest and immediately after exercise were assayed for metabolites, high-energy phosphates, and enzymes. Arterialized venous blood drawn at rest and after exercise was analyzed for lactate and [H+]. Respiratory measures were obtained on separate days during identical tests and during submaximal tests before and after training. Results — Pretraining, maximal resting activities of hexokinase, citrate synthase, and pyruvate dehydrogenase did not differ between groups. Muscle lactate accumulation with exercise was higher in type 1 diabetic than nondiabetic subjects and corresponded to indexes of glycemia (A1C, fasting plasma glucose); however, glycogenolytic and glycolytic rates were similar. Posttraining, at rest, hexokinase activity increased in type 1 diabetic subjects; in both groups, citrate synthase activity increased and pyruvate dehydrogenase activity decreased; during submaximal exercise, fat oxidation was higher; and during intense exercise, peak ventilation and carbon dioxide output, plasma lactate and [H+], muscle lactate, glycogenolytic and glycolytic rates, and ATP degradation were lower in both groups. Conclusions — High-intensity exercise training was well tolerated, reduced metabolic destabilization (of lactate, H+, glycogenolysis/glycolysis, and ATP) during intense exercise, and enhanced muscle oxidative metabolism in young adults with type 1 diabetes. The latter may have clinically important health benefits.

Item Type: Article
Uncontrolled Keywords: ResPubID16152, sprint-training effects, muscle metabolism, exercise, type 1 diabeties, metabolic destabilization, muscle oxidative metabolism
Subjects: FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1106 Human Movement and Sports Science
SEO Classification > 9399 Other Education and Training
Faculty/School/Research Centre/Department > Centre for Ageing, Rehabilitation, Exercise & Sport Science (CARES)
Related URLs:
Depositing User: VUIR
Date Deposited: 30 Sep 2011 01:19
Last Modified: 29 Jan 2015 05:33
URI: http://vuir.vu.edu.au/id/eprint/3697
DOI: 10.2337/dc08-0329
ePrint Statistics: View download statistics for this item
Citations in Scopus: 16 - View on Scopus

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