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Evaluation of mtDNA Mutations to Predict Age

Hewakapuge, Sudinna Kulangana and van Oorschot, Roland and Baindur-Hudson, Swati (2008) Evaluation of mtDNA Mutations to Predict Age. Forensic Science International: Genetics Supplement Series, 1 (1). pp. 561-562. ISSN 1875-1768

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Abstract

Ageing is a predictable, universal and detrimental process in humans. The ‘mitochondrial theory of ageing’ implies that the accumulation of mitochondrial DNA mutations, and the subsequent cytoplasmic segregation of these mutations during life, is an important contributor to the ageing process. Mitochondria have a separate autonomously replicating DNA genome and are maternally inherited. Previous research has identified accumulation of mutations in the ‘hypervariable regions’ (1 and 2) of the mitochondrial genome with age. In this study we analysed hypervariable region sequence variations within 12 separate families, eleven of three unbroken maternal lineages and one with four maternal lineages (ages 5– 96). Since mitochondria are maternally inherited, any sequence difference between the youngest member of the family compared with the others was considered to be age related. No age related mitochondrial mutations were observed in the 12 families analysed. Therefore, this methodology of direct sequencing of mitochondrial hypervariable regions does not appear to be a useful tool to assist in the prediction of the age of the person from whom a biological sample was collected at a crime scene.

Item Type: Article
Uncontrolled Keywords: ResPubID15839, mitochondrial DNA, ageing, maternal generations
Subjects: SEO Classification > 970106 Expanding Knowledge in the Biological Sciences
Faculty/School/Research Centre/Department > Centre for Ageing, Rehabilitation, Exercise & Sport Science (CARES)
FOR Classification > 0699 Other Biological Sciences
FOR Classification > 0604 Genetics
Depositing User: VUIR
Date Deposited: 22 Aug 2011 00:50
Last Modified: 21 Jan 2015 03:13
URI: http://vuir.vu.edu.au/id/eprint/3711
DOI: 10.1016/j.fsigss.2007.10.021
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Citations in Scopus: 0 - View on Scopus

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