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Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR (mRen-2)27 rats

Jayasooriya, Anura P and Begg, Denovan P and Chen, Nora and Mathai, Michael L and Sinclair, Andrew J and Wilkinson-Berka, J and Wark, John D and Weisinger, Harrison S and Weisinger, Richard S (2008) Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR (mRen-2)27 rats. Prostaglandins, Leukotrienes and Essential Fatty Acids, 78 (1). pp. 67-72. ISSN 0952-3278

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Abstract

To establish the effect of dietary o-3 PUFA on angiotensin II (ANG II)-mediated hypertension, male TGR (mRen-2)27 (Ren-2) rats (animals with high ANG II activity) were maintained on a diet either deficient or sufficient in o-3 PUFA from conception. Half the animals on each diet were treated with the angiotensin-converting enzyme inhibitor, perindopril, from birth. Ren-2 rats fed the o-3 PUFA deficient diet were significantly more hypertensive than those fed the o-3 PUFA sufficient diet. Perindopril reduced the blood pressure of both o-3 PUFA-deficient and o-3 PUFA-sufficient diet-fed Ren-2 rats. Body weight, body fat and plasma leptin were reduced by perindopril treatment but not affected by o-3 PUFA supply. Given that the elevated blood pressure of the Ren-2 rat is mediated by ANG II, the data suggest that o-3 PUFA may reduce hypertension via the renin–angiotensin system.

Item Type: Article
Uncontrolled Keywords: ResPubID16329, dietary reduction of hypertension, perindopril, reduction in blood pressure
Subjects: Faculty/School/Research Centre/Department > Other
FOR Classification > 1102 Cardiovascular Medicine and Haematology
FOR Classification > 0606 Physiology
Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
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Depositing User: VUIR
Date Deposited: 26 Aug 2011 05:38
Last Modified: 29 Jan 2015 03:49
URI: http://vuir.vu.edu.au/id/eprint/3734
DOI: 10.1016/j.plefa.2007.11.001
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Citations in Scopus: 16 - View on Scopus

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