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Intranasal naloxone for the treatment of suspected heroin overdose

Kerr, Debra and Dietze, Paul and Kelly, Anne-Maree (2008) Intranasal naloxone for the treatment of suspected heroin overdose. Addiction, 103 (3). pp. 379-386. ISSN 0965-2140

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Abstract

Aims - This paper reviews available literature regarding the effectiveness, safety and utility of intranasal (i.n.) naloxone for the treatment of heroin overdose. Methods - Scientific literature in the form of published articles during the period January 1984 to August 2007 were identified by searching several databases including Medline, Cinahl and Embase for the following terms: naloxone, narcan, intranasal, nose. The data extracted included study design, patient selection, numbers, outcomes and adverse events. Results - Reports of the pharmacological investigation and administration of i.n. naloxone for heroin overdose are included in this review. Treatment of heroin overdose by administration of i.n. naloxone has been introduced as first-line treatment in some jurisdictions in North America, and is currently under investigation in Australia. Conclusion - Currently there is not enough evidence to support i.n. naloxone as first-line intervention by paramedics for treatment of heroin overdose in the pre-hospital setting. Further research is required to confirmits clinical effectiveness, safety and utility. If proved effective, the i.n. route may be useful for drug administration in community settings (including peer-based administration), as it reduces risk of needlestick injury in a population at higher risk of blood-borne viruses. Problematically, naloxone is not manufactured currently in an ideal form for i.n. administration.

Item Type: Article
Uncontrolled Keywords: ResPubID14766, heroin, intranasal, naloxone, opioid, overdose, paramedic, resuscitation
Subjects: Faculty/School/Research Centre/Department > School of Nursing and Midwifery
FOR Classification > 1117 Public Health and Health Services
SEO Classification > 9202 Health and Support Services
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Depositing User: VUIR
Date Deposited: 31 Aug 2011 06:18
Last Modified: 31 Aug 2011 06:29
URI: http://vuir.vu.edu.au/id/eprint/3751
DOI: 10.1111/j.1360-0443.2007.02097.x
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Citations in Scopus: 10 - View on Scopus

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