Research Repository

Selective reduction in body fat mass and plasma leptin induced by angiotensin-converting enzyme inhibition in rats

Mathai, Michael L and Naik, Siang and Sinclair, Andrew J and Weisinger, Harrison S and Weisinger, Richard S (2008) Selective reduction in body fat mass and plasma leptin induced by angiotensin-converting enzyme inhibition in rats. International Journal of Obesity, 32 (10). pp. 1576-1584. ISSN 0307-0565

Full text for this resource is not available from the Research Repository.

Abstract

Objective: There is emerging evidence that angiotensin stimulates adipocyte differentiation and lipogenesis. This study tested the hypothesis that inhibition of angiotensin II by treatment with an angiotensin-converting enzyme inhibitor, perindopril, would reduce fat mass in rats. Design: After a 12-day baseline, rats were divided into two groups: one was untreated and the other received perindopril (1.2mgkg1 per day) in drinking water for 26 days. Subjects: In total, 16 male Sprague–Dawley rats aged 10 weeks at the start of the study. Measurements: Plasma leptin was measured in samples collected at baseline, half-way through and at the end of treatment. Body weight, food and water intake were measured daily throughout the experiment. Body fat mass, bone and lean mass were determined by dual energy X-ray absorptiometry (DEXA) at the end of the treatment period. Results: Daily food intake was the same in both groups throughout the study. By the end of treatment, animals receiving perindopril showed a modest reduction in weight gain relative to the untreated animals (62.4±5.0 g vs 73.0±4.0 g; Po0.05). DEXA analysis showed that body composition was greatly altered and the perindopril-treated group had 26% less body fat mass than the untreated group (61.0±5.2 g vs 44.4±4.2 g; Po0.01). The reduction in body fat mass was correlated with reductions in the weight of both the epididymal and retroperitoneal fat pads (Po0.001). Similarly, plasma leptin was reduced by perindopril treatment (4.64±0.56 ng ml1) compared to the untreated group (8.27±1.03 ng ml1; Po0.001). In contrast, there were no differences in lean or bone mass between the two groups. Conclusion: Oral treatment with perindopril selectively reduced body fat mass without influencing daily food intake. In contrast, there were no differences in lean or bone mass between the two groups.

Item Type: Article
Uncontrolled Keywords: ResPubID16333, body composition, leptin, appetite, fat-free mass
Subjects: Faculty/School/Research Centre/Department > Other
FOR Classification > 0606 Physiology
Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Related URLs:
Depositing User: VUIR
Date Deposited: 07 Sep 2011 03:23
Last Modified: 07 Sep 2011 03:23
URI: http://vuir.vu.edu.au/id/eprint/3816
DOI: 10.1038/ijo.2008.126
ePrint Statistics: View download statistics for this item
Citations in Scopus: 32 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar