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Cord Blood-Derived Mesenchymal Stem Cell Does Not Stimulate Nor Inhibits T Lymphocytes Activation

Tong, C and Seow, Heng and Ramasamy, R (2008) Cord Blood-Derived Mesenchymal Stem Cell Does Not Stimulate Nor Inhibits T Lymphocytes Activation. The Medical Journal of Malaysia, 63 (July - Suppl A). pp. 77-78. ISSN 0300-5283

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Abstract

The immune modulatory properties of mesenchymal stem cell (MSC) had brought a new insight in cell-based neotherapy. However, recent works of MSC are focused exclusively on bone marrow-derived MSC. We evaluated the immunogenicity of cord blood-derived MSC (CB-MSC) on T lymphocytes. Human peripheral blood mononuclear cells (PBMC) were prepared by density gradient separation and culture with the presence or absence of CB-MSC. PBMC were collected for activation analysis by flow cytometry at 24-, 48-, and 72- hours. The results showed that, CB-MSC does not stimulate nor inhibit T lymphocyte activation.

Item Type: Article
Uncontrolled Keywords: ResPubID15906. T-lymphocytes, mesenchymal, stem cells, mesenchymal stem cells, neotherapy, peripheral blood mononuclear cells
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1107 Immunology
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
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Depositing User: VUIR
Date Deposited: 04 Aug 2011 02:31
Last Modified: 11 Apr 2017 08:51
URI: http://vuir.vu.edu.au/id/eprint/4005
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Citations in Scopus: 4 - View on Scopus

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