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Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague-Dawley rats

Weisinger, Harrison S and Begg, Denovan P and Egan, Gary F and Jayasooriya, Anura P and Lie, Fanny and Mathai, Michael L and Sinclair, Andrew J and Weisinger, Richard S and Wark, John D (2008) Angiotensin converting enzyme inhibition from birth reduces body weight and body fat in Sprague-Dawley rats. Physiology and Behavior, 93 (4). pp. 820-825. ISSN 0031-9384

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Abstract

In vitro studies have demonstrated that angiotensin II (ANG II) induces adipocyte hyperplasia and hypertrophy. The aim of the present study was to determine the effect of angiotensin-converting enzyme inhibition on body weight, adiposity and blood pressure in Sprague-Dawley rats. From birth half of the animals (n=15) were given water to drink, while the remainder were administered perindopril in their drinking water (2 mg/kg/day). Food intake, water intake and body weight were measured weekly. Blood pressure was measured by tail cuff plethysmography at 11-weeks. Body fat content and distribution were assessed using dual energy X-ray absorptiometry and Magnetic Resonance Imaging at 12 weeks. Animals administered with perindopril had a body fat proportion that was half that of controls. This was consistent with, but disproportionately greater than the observed differences in food intake and body weight. Perindopril treatment completely removed hypertension. We conclude that the chronic inhibition of ANG II synthesis from birth specifically reduces the development of adiposity in the rat.

Item Type: Article
Uncontrolled Keywords: ResPubID16331. angiotensins, ACE, angiotensin converting enzyme, body fat, body weight, body weight inhibition, adiposity, blood pressure, laboratory rats, Sprague-Dawley rats
Subjects: FOR Classification > 0606 Physiology
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Faculty/School/Research Centre/Department > Other
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Depositing User: VUIR
Date Deposited: 05 Aug 2011 05:35
Last Modified: 05 Aug 2011 05:35
URI: http://vuir.vu.edu.au/id/eprint/4037
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Citations in Scopus: 21 - View on Scopus

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