Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells

Dargahi, Narges, Johnson, Joshua ORCID: 0000-0003-0000-5226 and Apostolopoulos, Vasso ORCID: 0000-0001-6788-2771 (2020) Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells. PLoS ONE, 15 (2). e0228531. ISSN 1932-6203

Abstract

© 2020 Dargahi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Consumption of probiotics contributes to a healthy microbiome of the GIT leading to many health benefits. They also contribute to the modulation of the immune system and are becoming popular for the treatment of a number of immune and inflammatory diseases. The main objective of this study was to evaluate anti-inflammatory and modulatory properties of Streptococcus thermophilus. We used peripheral blood mononuclear cells from healthy donors and assessed modifications in the mRNA expression of their genes related to innate and adaptive immune system. Our results showed strong immune modulatory effects of S. thermophilus 285 to human peripheral blood mononuclear cells with an array of anti-inflammatory properties. S. thermophilus 285 reduced mRNA expression in a number of inflammatory immune mediators and markers, and upregulated a few of immune markers. S. thermophilus is used in the dairy industry, survives during cold storage, tolerates well upon ingesting, and their consumption may have beneficial effects with potential implications in inflammatory and autoimmune disorders.

Item type Article
URI http://vuir.vu.edu.au/id/eprint/40712
Identification Number https://doi.org/10.1371/journal.pone.0228531
Official URL https://journals.plos.org/plosone/article/comments...
Subjects Current > FOR Classification > 1107 Immunology
Current > FOR Classification > 1108 Medical Microbiology
Current > Division/Research > Institute for Health and Sport
Current > Division/Research > Institute for Sustainable Industries and Liveable Cities
Keywords hygiene hypothesis ; probiotic bacteria ; gene expression ; anti-inflammatory immune-modulatory properties
Citations in Scopus 4 - View on Scopus
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