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Calcitonin gene–related peptide inhibits angiotensin II–mediated vasoconstriction in human radial arteries: Role of the Kir channel

Zulli, Anthony and Ye, Bei and Wookey, Peter J and Buxton, Brian F and Hare, David L (2008) Calcitonin gene–related peptide inhibits angiotensin II–mediated vasoconstriction in human radial arteries: Role of the Kir channel. Journal of Thoracic and Cardiovascular Surgery, 136 (2). pp. 370-375. ISSN 0022-5223

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Abstract

The radial artery is increasingly used for coronary artery bypass grafts, but its potential for spasm increases postoperative risk. Alpha-calcitonin gene–related peptide is a potent antihypertensive peptide. Thus, we set out to determine whether calcitonin gene–related peptide can impair angiotensin II–mediated vasoconstriction in human radial arteries and, if so, to determine its mechanism of action.

Item Type: Article
Uncontrolled Keywords: ResPubID17594, ResPubID22030. peptides, angiotensin II, vasoconstriction, human radial arteries, Kir channel, calcitonin gene–related peptide, coronary artery bypass grafts
Subjects: FOR Classification > 1102 Cardiovascular Medicine and Haematology
FOR Classification > 1101 Medical Biochemistry and Metabolomics
Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Depositing User: VUIR
Date Deposited: 17 Aug 2011 01:08
Last Modified: 20 Jan 2015 03:56
URI: http://vuir.vu.edu.au/id/eprint/4106
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Citations in Scopus: 3 - View on Scopus

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