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2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans

Lim, Crystale Siew-Ying, Wong, Won-Fen, Rosli, Rozita, Ng, Kee-Peng, Seow, Heng-Fong and Chong, Pei Pei (2009) 2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans. Journal of Basic Microbiology, 49 (6). pp. 579-583. ISSN 0233-111X, 15214028(online)

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Candida albicans is capable of undergoing yeast-hypha transition to attain pathogenicity in humans. In this study, we investigated the differential expression of CaSIR2 via quantitative real-time PCR (qPCR), during yeast-hypha transition with and without the presence of 2-dodecanol. SIR2 transcript levels were found to be significantly enhanced after hyphal induction as compared to the yeast form. This study found that 2-dodecanol is able to inhibit hyphal development and block SIR2 up-regulation, even in hyphal-inducing growth conditions. We suggest that SIR2 may be involved in Candida albicans quorum-sensing and serum-induced yeast-hyphae transition via the Ras1-cAMP-Efg1 signalling cascade

Item Type: Article
Uncontrolled Keywords: ResPubID19163, ResPubID19157. Candida albicans, SIR2 gene, quantitative real-time PCR, gene expression, dodecanol
Subjects: Current > FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Depositing User: VUIR
Date Deposited: 02 May 2012 05:39
Last Modified: 29 Jan 2015 22:13
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Citations in Scopus: 8 - View on Scopus

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