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Nanoparticle-mediated interleukin-12 cancer gene therapy

Hallaj-Nezhadi, Somayeh and Lotfipour, Farzaneh and Dass, Crispin R (2010) Nanoparticle-mediated interleukin-12 cancer gene therapy. Journal of Pharmacy and Pharmaceutical Sciences , 13 (3). pp. 472-485. ISSN 1482-1826 (online) 1482-1826 (print)

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Abstract

Interleukin-12 (Il-12) is a heterodimeric cytokine which has been proved to possess antitumor effects in various animal models via stimulating the immune system. The main problem associated with Il-12 protein delivery is its instability as well as cytotoxicity subsequent to systemic administration in rodents and in human clinical trials. However, gene delivery can be used to deliver genes of interest to the tumor site. Hence, a large number of studies have been undertaken to deliver genes of interest to the tumor site through viral or non-viral vectors. Viral DNA delivery systems suffer from safety concern due to the toxicity of the viruses and strong immune response; while non-viral gene delivery systems proffer lower transfection efficiency. Nevertheless, nanometer-size complex of therapeutic DNA may demonstrate more efficient for administration of therapeutic genes to solid tumors compared to administration of naked plasmid DNA. Nanoparticle-based gene delivery systems might be more pertinent, due to the enhanced tissue penetrability, improved cellular uptake. Il-12 gene delivery has already been reported with different nanoparticles containing DNA. This article provides a review on the in vivo and in vitro studies using various nanoparticles, for delivery of the Il-12 genes to neoplastic cells. The future of these promising approaches lies in the development of better techniques for preparing il-12 gene delivery systems with complete efficiency of viral vectors in addition to the highest safety for cancer patients.

Item Type: Article
Uncontrolled Keywords: ResPubID21627, gene therapy, nanoparticle-mediated, Interleukin-12, immune system, DNA
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Depositing User: VUIR
Date Deposited: 20 May 2012 23:15
Last Modified: 23 Mar 2015 03:02
URI: http://vuir.vu.edu.au/id/eprint/7155
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Citations in Scopus: 6 - View on Scopus

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