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The applied biochemistry of PEDF and implications for tissue homeostasis

Broadhead, Matthew L and Becerra, S. Patricia and Choong, Peter F. M and Dass, Crispin R (2010) The applied biochemistry of PEDF and implications for tissue homeostasis. Growth Factors, 28 (4). pp. 280-285. ISSN 0897-7194

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Abstract

Pigment epithelium-derived factor (PEDF) is an endogenously produced glycoprotein with a spectrum of biological roles across diverse pathologies. Recent research has focused on the biochemical properties of PEDF and its associated receptors. This review discusses the recent developments in PEDF biochemistry and how this new knowledge will help progress our understanding of PEDF as a molecular mediator for anti-angiogenesis and -tumorigenesis. Additionally, pathophysiological roles for PEDF in healing and tissue homeostasis are being revealed and our enhanced understanding of the interactions between PEDF and its receptors may yet prove useful in propelling PEDF towards clinical application.

Item Type: Article
Uncontrolled Keywords: ResPubID21857. pigment epithelium derived factor, structure, receptor, biochemistry, healing, repair, PEDF, anti-angiogenic, angiogenesis inhibitors, eye growth, eye proteins, antineoplastic, serpins, anti-tumorigenesis, cancer
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1103 Clinical Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
FOR Classification > 1116 Medical Physiology
SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
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Depositing User: VUIR
Date Deposited: 02 Feb 2012 04:16
Last Modified: 27 Jan 2015 22:58
URI: http://vuir.vu.edu.au/id/eprint/7562
DOI: 10.3109/08977191003604513
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Citations in Scopus: 6 - View on Scopus

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