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Microarray: an instrument for cancer surgeons of the future? : Surgical science

Broadhead, Matthew L, Clark, Jonathan C. M, Dass, Crispin R and Choong, Peter F. M (2010) Microarray: an instrument for cancer surgeons of the future? : Surgical science. ANZ Journal of Surgery, 80 (7-8). pp. 531-536. ISSN 1445-1433

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Abstract

Microarray enables the study of thousands of genes simultaneously. While still in its infancy as a technique and with a number of barriers to be overcome, microarray is allowing scientists to thoroughly examine the molecular pathways of cancer pathogenesis. However, the adoption of microarray as a clinically applicable technique has been slow coming. Current literature suggests roles in the diagnosis of tumours of unknown origin, in the evaluation of prognostic markers, and in guiding treatment for recurrent and resistant malignancy. This review outlines the science of microarray and draws on clinical examples, including osteosarcoma, breast, prostate and pancreatic carcinomas, to highlight the potential of microarray as a technique of surgical importance.

Item Type: Article
Additional Information:

Online ISSN: 1445-2197

Uncontrolled Keywords: ResPubID21858. microarray, osteosarcoma, bone cancer, breast cancer, prostate cancer, pancreas cancer, tumours, cancer pathogenesis, cancer therapy, genetic profiles, prognostic markers, chemoresistance, prognosis
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1103 Clinical Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Depositing User: VUIR
Date Deposited: 15 Nov 2011 00:09
Last Modified: 28 Jan 2015 05:27
URI: http://vuir.vu.edu.au/id/eprint/7563
DOI: https://doi.org/10.1111/j.1445-2197.2010.05379.x
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Citations in Scopus: 5 - View on Scopus

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