Anti-Tumour Effect of a Chitosan Delivery System for Doxorubicin

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Tan, M, Choong, Peter F. M and Dass, Crispin R (2010) Anti-Tumour Effect of a Chitosan Delivery System for Doxorubicin. Advanced Materials Research, 93-94 (2010). pp. 703-706. ISSN 1022-6680 (print) 1662-8985 (online)

Abstract

Used against a variety of tumours, doxorubicin (DOX), causes multiple side-effects in patients, especially in high doses required to control tumour growth. A drug delivery system (DDS) was developed to deliver DOX. Through DOX encapsulation into chitosan DDS, novel DOX microparticles (DMPs) were formed. Multiple optimisation steps produced DMPs which caused tumour cell death. Treatment of mice bearing tumours with DMP decreased tumour growth and spread, with no visible side-effects. There are plans to evaluate this delivery vehicle more closely towards clinical development and testing.

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Item type	Article
URI	https://vuir.vu.edu.au/id/eprint/7573
DOI	10.4028/www.scientific.net/AMR.93-94.703
Subjects	Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences Historical > FOR Classification > 1112 Oncology and Carcinogenesis Historical > SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Keywords	ResPubID21869, cancer, chitosan, complex, delivery, doxorubicin
Citations in Scopus	1 - View on Scopus
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