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Anti-Tumour Effect of a Chitosan Delivery System for Doxorubicin

Tan, M and Choong, Peter F. M and Dass, Crispin R (2010) Anti-Tumour Effect of a Chitosan Delivery System for Doxorubicin. Advanced Materials Research, 93-94 (2010). pp. 703-706. ISSN 1022-6680 (print) 1662-8985 (online)

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Abstract

Used against a variety of tumours, doxorubicin (DOX), causes multiple side-effects in patients, especially in high doses required to control tumour growth. A drug delivery system (DDS) was developed to deliver DOX. Through DOX encapsulation into chitosan DDS, novel DOX microparticles (DMPs) were formed. Multiple optimisation steps produced DMPs which caused tumour cell death. Treatment of mice bearing tumours with DMP decreased tumour growth and spread, with no visible side-effects. There are plans to evaluate this delivery vehicle more closely towards clinical development and testing.

Item Type: Article
Uncontrolled Keywords: ResPubID21869, cancer, chitosan, complex, delivery, doxorubicin
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
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Depositing User: VUIR
Date Deposited: 25 Jun 2012 03:55
Last Modified: 25 Jun 2012 03:55
URI: http://vuir.vu.edu.au/id/eprint/7573
DOI: 10.4028/www.scientific.net/AMR.93-94.703
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Citations in Scopus: 1 - View on Scopus

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