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A chitosan hydrogel delivery system for osteosarcoma gene therapy with pigment epithelium-derived factor combined with chemotherapy

Ta, Hang T and Dass, Crispin R and Larson, Ian and Choong, Peter F. M and Dunstan, David E (2009) A chitosan hydrogel delivery system for osteosarcoma gene therapy with pigment epithelium-derived factor combined with chemotherapy. Biomaterials, 30 (27). pp. 4815-4823. ISSN 0142-9612

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Abstract

Osteosarcoma (OS) is the most common type of malignant bone cancer, and the sixth most common type of cancer in children and young adults. Currently, gene therapy is being evaluated as a novel method for OS treatment. Here we report on an in situ gelling chitosan-based hydrogel system that sustains the release of a potential anti-cancer gene (pigment epithelium-derived factor) to the tumor site. A significant reduction of the primary OS in a clinically relevant orthotopic model was measured. The combination of plasmid treatment and chemotherapy together with the use of this delivery system led to the highest suppression of tumor growth without side effects. The results obtained from this study demonstrate the potential application of a biodegradable hydrogel technology as an anti-cancer drug delivery system for successful chemo-gene therapy.

Item Type: Article
Uncontrolled Keywords: ResPubID21877. chitosan, orthophosphate, drug delivery, hydrogel, osteosarcoma, bone cancer, gene therapy, cancer therapy, pigment epithelium-derived factor, tumours, chemotherapy
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Depositing User: VUIR
Date Deposited: 31 Oct 2011 04:11
Last Modified: 10 Feb 2015 04:06
URI: http://vuir.vu.edu.au/id/eprint/7581
DOI: 10.1016/j.biomaterials.2009.05.035
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Citations in Scopus: 27 - View on Scopus

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