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A chitosan-dipotassium orthophosphate hydrogel for the delivery of Doxorubicin in the treatment of osteosarcoma

Ta, Hang T and Dass, Crispin R and Larson, Ian and Choong, Peter F. M and Dunstan, David E (2009) A chitosan-dipotassium orthophosphate hydrogel for the delivery of Doxorubicin in the treatment of osteosarcoma. Biomaterials, 30 (21). pp. 3605-3613. ISSN 0142-9612

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Abstract

The current management of primary osteosarcoma (OS) and its secondary metastasis is limited by the lack of an efficient drug delivery system. Herewe report an in situ gelling chitosan/dipotassium orthophosphate hydrogel system designed to directly deliver the frontline chemotherapeutic agent (Doxorubicin) in a sustained time period to tumor sites. A significant reduction of both primary and secondary OS in a clinically relevant orthotopic model was measured when doxorubicin was administered with the hydrogel. This hydrogel delivery system also reduced cardiac and dermal toxicity of Doxorubicin in mice. The results obtained from this study demonstrate the potential application of a biodegradable hydrogel technology as an anti-cancer drug delivery system for successful chemotherapy.

Item Type: Article
Uncontrolled Keywords: ResPubID21878. chitosan, orthophosphate, drug delivery, hydrogel, osteosarcoma, bone cancer, chemotherapy, Doxorubicin, tumours
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Depositing User: VUIR
Date Deposited: 31 Oct 2011 04:53
Last Modified: 10 Feb 2015 04:05
URI: http://vuir.vu.edu.au/id/eprint/7582
DOI: 10.1016/j.biomaterials.2009.03.022
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Citations in Scopus: 41 - View on Scopus

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