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Osteosarcoma treatment: state of the art

Ta, Hang T, Dass, Crispin R, Choong, Peter F. M and Dunstan, David E (2009) Osteosarcoma treatment: state of the art. Cancer and Metastasis Reviews, 28 (1-2). pp. 247-263. ISSN 0167-7659

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Abstract

Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or young adults. It is the second highest cause of cancer-related death in these age groups, mainly due to development of often fatal metastasis, usually in the lungs. Survival for these patients is poor despite the aggressive use of surgery, chemotherapy, and/or radiotherapy. Thus, new effective drugs and other forms of therapy are needed. This article reviews the biology and the state of the art management of OS. New experimental drugs and potential therapies targeting molecular pathways of OS are also discussed.

Item Type: Article
Uncontrolled Keywords: ResPubID21881. osteosarcoma, tumours, bone cancer, chemotherapy, radiotherapy, cancer therapy lung metastasis
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Depositing User: VUIR
Date Deposited: 31 Oct 2011 03:35
Last Modified: 10 Feb 2015 04:15
URI: http://vuir.vu.edu.au/id/eprint/7584
DOI: https://doi.org/10.1007/s10555-009-9186-7
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Citations in Scopus: 212 - View on Scopus

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