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c-Jun is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.

Dass, Crispin R and Khachigian, Levon M and Choong, Peter F. M (2008) c-Jun is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model. Molecular Cancer Research, 6 (8). pp. 1289-1292. ISSN 1541-7786

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Abstract

The oncogene c-Jun has been found to be up-regulated in a variety of cancers including osteosarcoma. DNA enzymes (DNAzymes) are oligonucleotides capable of specific catalysis of target mRNA. A c-Jun DNAzyme inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasizing model of the disease. c-Jun down-regulation–mediated apoptosis in osteosarcoma cells involved caspase-1, caspase-2, and caspase-8, but not the Fas/FasL pathway. Clinically, knockdown of c-Jun with DNAzymes may proffer an improved treatment outcome for these tumors originating in bone. A correction to this article has also been published.

Item Type: Article
Uncontrolled Keywords: ResPubID21889, ResPubID18867, c-Jun, cancer, apoptosis, deoxyribozyme, oncogene, bone, osteosarcoma, orthotopic, spontaneously metastasizing model, metastasis, DNAzyme
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Depositing User: VUIR
Date Deposited: 24 Oct 2011 01:36
Last Modified: 10 Mar 2015 06:17
URI: http://vuir.vu.edu.au/id/eprint/7592
DOI: 10.1158/1541-7786.MCR-08-0036
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Citations in Scopus: 21 - View on Scopus

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