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PEDF: a potential molecular therapeutic target with multiple anti-cancer activities

Ek, Eugene T. H and Dass, Crispin R and Choong, Peter F. M (2006) PEDF: a potential molecular therapeutic target with multiple anti-cancer activities. Trends in Molecular Medicine, 12 (10). pp. 497-502. ISSN 1471-4914

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Abstract

Pigment epithelium-derived factor (PEDF) is an endogenously produced protein that is widely expressed throughout the human body, and exhibits multiple and varied biological activities. Already established as a potent anti-angiogenic molecule, PEDF has recently shown promise as a potential anti-tumour agent, causing both direct and indirect tumour suppression. Here, we explore the unique anti-tumour properties of PEDF and discuss its role as an effective anti-angiogenic, anti-proliferative and pro-differentiation factor. We also discuss the prospects for PEDF therapy and the need for a closer evaluation of issues such as delivery, stability and potential toxicity.

Item Type: Article
Uncontrolled Keywords: ResPubID21891. pigment epithelium-derived factor, PEDF, anti-cancer activity, molecular therapy, cancer, tumours, anti-angiogenic, anti-tumour
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Depositing User: VUIR
Date Deposited: 21 Oct 2011 03:44
Last Modified: 03 Dec 2014 04:22
URI: http://vuir.vu.edu.au/id/eprint/7593
DOI: 10.1016/j.molmed.2006.08.009
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Citations in Scopus: 81 - View on Scopus

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