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Targeting of small molecule anticancer drugs to the tumour and its vasculature using cationic liposomes: lessons from gene therapy

Dass, Crispin R and Choong, Peter F. M (2006) Targeting of small molecule anticancer drugs to the tumour and its vasculature using cationic liposomes: lessons from gene therapy. Cancer Cell International, 6. ISSN 1475-2867

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Abstract

Cationic (positively charged) liposomes have been tested in various gene therapy clinical trials for neoplastic and other diseases. They have demonstrated selectivity for tumour vascular endothelial cells raising hopes for both antiangiogenic and antivascular therapies. They are also capable of being selectively delivered to the lungs and liver when administered intravenously. These vesicles are being targeted to the tumour in various parts of the body by using advanced liposomal systems such as ligand-receptor and antibody-antigen combinations. At present, the transferrin receptor is commonly used for cancer-targeted drug delivery systems including cationic liposomes. This review looks at the growing utility of these vesicles for delivery of small molecule anticancer drugs.

Item Type: Article
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June 2006 issue, (article 17)

Uncontrolled Keywords: ResPubID21892. small molecule anti-cancer drugs, tumours, cancer, liposomes, gene therapy, tumour vascular endothelial cells
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1112 Oncology and Carcinogenesis
SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
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Depositing User: VUIR
Date Deposited: 12 Dec 2011 23:26
Last Modified: 03 Feb 2015 00:22
URI: http://vuir.vu.edu.au/id/eprint/7594
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Citations in Scopus: 31 - View on Scopus

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