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Editorial: Making gene therapy for osteosarcoma a reality

Broadhead, Matthew L and Clark, Jonathan C. M and Choong, Peter F. M and Dass, Crispin R (2010) Editorial: Making gene therapy for osteosarcoma a reality. Expert Review of Anticancer Therapy, 10 (4). pp. 477-480. ISSN 1473-7140

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Abstract

Gene therapy for osteosarcoma is gaining additional momentum with the introduction of delivery vehicles such as hydrogels [52] and modified adenoviral vectors. With safer gene-delivery vehicles being produced, nucleic acid-based therapeutic constructs are becoming more amenable to clinical application. Targets such as ezrin [24], uPAR [28,29] and PEDF [30–32] have been shown to be efficacious for osteosarcoma in animal models. A combination of gene therapy and conventional therapies may yet achieve more complete disease control and warrants further evaluation for osteosarcoma.

Item Type: Article
Uncontrolled Keywords: ResPubID21867. osteosarcoma, bone cancer, gene therapy, cancer therapy, tumours, viral vector, nonviral-mediated gene therapy, animal models
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1112 Oncology and Carcinogenesis
SEO Classification > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Depositing User: VUIR
Date Deposited: 14 Nov 2011 23:39
Last Modified: 28 Jan 2015 05:28
URI: http://vuir.vu.edu.au/id/eprint/7597
DOI: 10.1586/era.10.18
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Citations in Scopus: 6 - View on Scopus

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