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Effects of high-intensity training on muscle lactate transporters and postexercise recovery of muscle lactate and hydrogen ions in women

Bishop, David, Edge, Johann, Thomas, Claire and Mercier, Jacques (2008) Effects of high-intensity training on muscle lactate transporters and postexercise recovery of muscle lactate and hydrogen ions in women. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 295 (6). R1991-R1998. ISSN 0363-6119

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Abstract

The purpose of this study was to investigate the effects of high-intensity interval training (3 days/wk for 5 wk), provoking large changes in muscle lactate and pH, on changes in intracellular buffer capacity (βmin vitro), monocarboxylate transporters (MCTs), and the decrease in muscle lactate and hydrogen ions (H+) after exercise in women. Before and after training, biopsies of the vastus lateralis were obtained at rest and immediately after and 60 s after 45 s of exercise at 190% of maximal O2 uptake. Muscle samples were analyzed for ATP, phosphocreatine (PCr), lactate, and H+; MCT1 and MCT4 relative abundance and βmin vitro were also determined in resting muscle only. Training provoked a large decrease in postexercise muscle pH (pH 6.81). After training, there was a significant decrease in βmin vitro (–11%) and no significant change in relative abundance of MCT1 (96 ± 12%) or MCT4 (120 ± 21%). During the 60-s recovery after exercise, training was associated with no change in the decrease in muscle lactate, a significantly smaller decrease in muscle H+, and increased PCr resynthesis. These results suggest that increases in βmin vitro and MCT relative abundance are not linked to the degree of muscle lactate and H+ accumulation during training. Furthermore, training that is very intense may actually lead to decreases in βmin vitro. The smaller postexercise decrease in muscle H+ after training is a further novel finding and suggests that training that results in a decrease in H+ accumulation and an increase in PCr resynthesis can actually reduce the decrease in muscle H+ during the recovery from supramaximal exercise.

Item Type: Article
Additional Information:

Online ISSN: 1522-1490

Uncontrolled Keywords: ResPubID22016. buffer capacity, monocarboxylate transporter 1, monocarboxylate transporter 4, phosphocreatine resynthesis, females, women, intense exercise, muscle lactate, hydrogen ions, interval training
Subjects: FOR Classification > 1106 Human Movement and Sports Science
Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Depositing User: VUIR
Date Deposited: 13 Apr 2012 06:40
Last Modified: 13 Mar 2015 03:12
URI: http://vuir.vu.edu.au/id/eprint/7981
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Citations in Scopus: 34 - View on Scopus

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