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Hypothalamic regulatory pathways and potential obesity treatment targets

Jobst, Erin E and Enriori, Pablo J and Sinnayah, Puspha and Cowley, Michael A (2006) Hypothalamic regulatory pathways and potential obesity treatment targets. Endocrine, 29 (1). pp. 33-48. ISSN 0969-711X

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Abstract

With an ever-growing population of obese people as well as comorbidities associated with obesity, finding effective weight loss strategies is more imperative than ever. One of the challenges in curbing the obesity crisis is designing successful strategies for long-term weight loss and weight-loss maintenance. Currently, weight-loss strategies include promotion of therapeutic lifestyle changes (diet and exercise), pharmacological therapy, and bariatric surgery. This review focuses on several pharmacological targets that activate central nervous system pathways that normally limit food intake and body weight. Though it is likely that no single therapy will prove effective for everyone, this review considers several recent pre-clinical targets, and several compounds that have been in human clinical trials.

Item Type: Article
Additional Information:

Online ISSN: 1559-0100

Uncontrolled Keywords: ResPubID22129. obesity, weight-loss, hypothalamus, drug targets, melanocortin, NPY, MCH, cannabinoid, CART, CNTF, AMP kinase, topiramate
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1115 Pharmacology and Pharmaceutical Sciences
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Depositing User: VUIR
Date Deposited: 07 Feb 2012 03:02
Last Modified: 03 Feb 2015 05:35
URI: http://vuir.vu.edu.au/id/eprint/8083
DOI: 10.1385/ENDO:29:1:33
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Citations in Scopus: 6 - View on Scopus

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