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CD34 Class III positive cells are present in atherosclerotic plaques of the rabbit model of atherosclerosis

Zulli, Anthony and Buxton, Brian F and Black, M. Jane and Hare, David L (2005) CD34 Class III positive cells are present in atherosclerotic plaques of the rabbit model of atherosclerosis. Histochemistry and Cell Biology, 124 (6). pp. 517-522. ISSN 0948-6143

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Abstract

CD34 is a positive marker for haematopoietic stem cells and endothelial cells. Recent evidence suggests that haematopoietic progenitor cells are involved in atherogenesis. CD34-positive haematopoietic progenitor cells have never been described in rabbit atherosclerotic tissues. The aim of this study is to identify CD34-positive haematopoietic progenitor cells in rabbit atherosclerotic tissues, and to compare this with macrophage (RAM-11), alpha smooth muscle cell actin and fibroblast (prolyl-4-hydroxylase) immunoreactive cells. Sixteen Male New Zealand White rabbits were divided into two groups: Group 1, control diet (Con); group 2, 0.5% cholesterol diet, and killed after 12 weeks. Immunohistochemistry was used to detect CD34 haematopoietic progenitor cells. CD34-positive haematopoietic progenitor cells were identified both within and overlying atherosclerotic plaques. As well, these haematopoietic progenitor cells also stained for RAM-11, CD45, prolyl-4 hydroxylase and alpha smooth muscle cell actin. These findings suggest that in the rabbit model of atherosclerosis, the previously identified macrophages, smooth muscle cells and fibroblasts within and overlying atherosclerotic plaques might be of haematopoietic origin.

Item Type: Article
Additional Information:

Online ISSN: 1432-119X

Uncontrolled Keywords: ResPubID22148. rabbits, CD34, CD45, atherosclerosis, immunohistochemistry, fibroblast, arteries, plaques
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1102 Cardiovascular Medicine and Haematology
Depositing User: VUIR
Date Deposited: 19 Jan 2012 03:07
Last Modified: 28 Jan 2015 01:05
URI: http://vuir.vu.edu.au/id/eprint/8099
DOI: 10.1007/s00418-005-0072-2
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Citations in Scopus: 15 - View on Scopus

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