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Cancer stem cells in breast cancer and metastasis

Lawson, Jessica C, Blatch, Gregory L and Edkins, Adrienne L (2009) Cancer stem cells in breast cancer and metastasis. Breast Cancer Research and Treatment, 118 (2). pp. 241-254. ISSN 0167-6806 (print) 1573-7217 (online)

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Abstract

The cancer stem cell theory poses that cancers develop from a subset of malignant cells that possess stem cell characteristics and has been proposed to account for the development of a variety of malignancies, including breast cancer. These cancer stem cells (CSC) possess characteristics of both stem cells and cancer cells, in that they have the properties of self-renewal, asymmetric cell division, resistance to apoptosis, independent growth, tumourigenicity and metastatic potential. A CSC origin for breast cancer can neatly explain both the heterogeneity of breast cancers and the relapse of the tumours after treatment. However, many reports on CSC in the breast are contradictory. There is variation with respect to how breast cancer stem cells should be identified, their characteristics and a possible lack of correlation between clinical outcome and breast cancer stem cell status of a tumour. These combined factors have made breast cancer stem cells a highly contentious issue. In this review, we highlight the progress in the analysis of cancer stem cells, with an emphasis on breast cancer.

Item Type: Article
Uncontrolled Keywords: ResPubID22190. tumourigenicity, malignant, malignancy, tumours, Hsp90, heat sensitive proteins, cancer development, CD44+, CD42-
Subjects: FOR Classification > 1112 Oncology and Carcinogenesis
Faculty/School/Research Centre/Department > School of Social Sciences and Psychology
Depositing User: VUIR
Date Deposited: 12 Jun 2012 07:03
Last Modified: 18 Mar 2015 02:47
URI: http://vuir.vu.edu.au/id/eprint/8136
DOI: https://doi.org/10.1007/s10549-009-0524-9
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Citations in Scopus: 76 - View on Scopus

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