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3-Substituted Anilines as Scaffolds for the Construction of Glutamine Synthetase and DXP-Reductoisomerase Inhibitors

Mutorwa, Marius and Salisu, Sheriff and Blatch, Gregory L and Kenyon, Colin and Kaye, Perry T (2009) 3-Substituted Anilines as Scaffolds for the Construction of Glutamine Synthetase and DXP-Reductoisomerase Inhibitors. Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry , 39 (15). pp. 2723-2736. ISSN 0039-7911

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Abstract

Access to a series of truncated ATP analogs, as potential anti-tuberculosis agents, has been explored via alkylation and acylation of 3-aminophenol, whereas chloroacetylation, using chloroacetyl chloride, and subsequent Arbuzov phosphonation of a series of 3-substituted anilines have afforded a series of phosphonate derivatives as potential antimalarial agents.

Item Type: Article
Uncontrolled Keywords: ResPubID22192, aniline derivatives, DXP-reductoisomerase inhibitors, glutamine synthetase, phosphonates
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
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Depositing User: VUIR
Date Deposited: 12 Jul 2012 06:34
Last Modified: 10 Mar 2015 03:48
URI: http://vuir.vu.edu.au/id/eprint/8138
DOI: 10.1080/00397910802663444
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Citations in Scopus: 3 - View on Scopus

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