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Isolation of a mouse cDNA encoding mSTI1, a stress-inducible protein containing the TPR motif

Blatch, Gregory L and Lässle, M and Zetter, B and Kundra, V (1997) Isolation of a mouse cDNA encoding mSTI1, a stress-inducible protein containing the TPR motif. Gene, 194 (2). pp. 277-282. ISSN 0378-1119

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Abstract

We report the isolation and sequencing of the complete 2079-bp cDNA fragment encoding mSTI1, a murine stress-inducible protein. The predicted ORF encodes a protein of 543 amino acids (aa) and Mr 62 582. The predicted protein has significant homology to stress-inducible proteins from humans (IEF SSP 3521), soybean (GMSTI), yeast (STI1) and a parasite, Leishmania donovani (LSIP). All of these proteins contain 34-aa repeat motifs, termed tetratricopeptide repeats (TPRs), that are proposed to be involved in intra- and intermolecular protein interactions. mSTI1 has ten potential TPR motifs, a putative nuclear localization signal (NLS), six potential phosphorylation sites for casein kinase II and a central proline-rich region. Western analysis detected a protein of approx. 63 kDa in all the major mouse organs and in mouse, monkey and human cell lines.

Item Type: Article
Uncontrolled Keywords: ResPubID22236. STI1, IEF SSP 3521, p60, Hop, RF-hsp70, GMSTI, LSIP, mouse cDNA, DNA, TPR motif, mice, proteins
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 0604 Genetics
Depositing User: VUIR
Date Deposited: 12 Dec 2011 04:00
Last Modified: 12 Dec 2011 04:00
URI: http://vuir.vu.edu.au/id/eprint/8181
DOI: 10.1016/S0378-1119(97)00206-0
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Citations in Scopus: 36 - View on Scopus

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