Research Repository

A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas

Henson, Jereym and Hannay, Jonathan and McCarthy, Stanley and Royds, Janice and Yeager, Thomas and Robinson, Robert and Wharton, Stephen and Jellinek, David and Arbuckle, Susan and Yoo, Jinyoung and Robinson, Bruce and Learoyd, Diana and Stalley, Paul and Bonar, Fiona and Yu, Dihua and Pollock, Raphael and Reddel, Roger (2005) A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas. Clinical Cancer Research, 11 (1). pp. 217-225. ISSN 1078-0432

Full text for this resource is not available from the Research Repository.

Abstract

Telomeres of tumor cells may be maintained by telomerase or by alternative lengthening of telomeres (ALT). The standard ALT assay requires Southern analysis of high molecular weight genomic DNA. We aimed to establish and validate an ALT assay suitable for archived paraffin-embedded tumors and to use it to examine the prevalence and clinical significance of ALT in various types of tumors that are often telomerase negative.

Item Type: Article
Additional Information:

Online ISSN: 1557-3265

Uncontrolled Keywords: ResPubID19460, ResPubID22569. ALT-associated PML body, soft tissue sarcoma, astrocytoma, osteosarcoma, bone cancer, glioblastoma multiforme, papillary carcinoma of thyroid, assay, tumours, telomeres, leukemia, DNA
Subjects: Faculty/School/Research Centre/Department > School of Engineering and Science
FOR Classification > 1112 Oncology and Carcinogenesis
Depositing User: VUIR
Date Deposited: 22 Dec 2011 03:08
Last Modified: 02 Feb 2012 00:55
URI: http://vuir.vu.edu.au/id/eprint/8496
ePrint Statistics: View download statistics for this item
Citations in Scopus: 113 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar