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Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors : a 12-month randomized controlled weight loss trial

Belski, Regina and Mori, T. A and Puddey, I. B and Sipsas, S and Woodman, R. J and Ackland, T. R and Beilin, L. J and Dove, E. R and Carlyon, N. B and Jayaseena, V and Hodgson, J. M (2011) Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors : a 12-month randomized controlled weight loss trial. International Journal of Obesity, 35. pp. 810-819. ISSN 0307-0565

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Abstract

Background: Regular consumption of diets with increased protein or fibre intakes may benefit body weight and composition and cardiovascular disease risk factors. Lupin flour is a novel food ingredient high in protein and fibre. Objective: To investigate the effects of a lupin-enriched diet, during and following energy restriction, on body weight and composition and cardiovascular disease risk factors in overweight individuals. Design: Participants (n=131) were recruited to a 12-month parallel-design trial. They were randomly assigned to consume lupin-enriched foods or matching high-carbohydrate control foods. All participants underwent 3 months of weight loss, 1 month of weight stabilization and 8 months of weight maintenance. Body weight and composition and cardiovascular disease risk factors were assessed at baseline, 4 and 12 months. Results: Lupin, relative to control, did not significantly influence (mean difference (95% CI)) weight loss at 4 months (0.1 kg (-1.2, 1.4)) and 12 months (-0.6 kg (-2.0, 0.8)), maintenance of weight loss from 4 to 12 months (-0.7 kg (-1.83, 0.48)) or measures of body fat and fat-free mass. Relative to control, 24-h ambulatory systolic ( 1.3mmHg (-2.4, -0.3), P=0.016) and diastolic (-1.0mmHg (-1.9, -0.2), P=0.021) blood pressures were lower at 12 months but not at 4 months; fasting insulin concentrations and homeostasis model assessment (HOMA) scores were significantly lower at 4 months (-1.2mUl–1 (-1.3, -1.1), P=0.004 and -0.6 units (-1.0, -0.19), P=0.004) and 12 months (-1.3 mUl–1 (-1.4, -1.1), P<0.001 and -0.7 units (-1.1, -0.24), P=0.002). Conclusions: A diet higher in protein and fibre derived from lupin-enriched foods does not enhance weight loss or improve the maintenance of weight loss. However, such a diet may provide cardiovascular health benefits in terms of insulin sensitivity and blood pressure.

Item Type: Article
Uncontrolled Keywords: ResPubID19572, lupin, weight loss, blood pressure, insulin, lipids
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1102 Cardiovascular Medicine and Haematology
Depositing User: VUIR
Date Deposited: 22 Dec 2011 00:34
Last Modified: 14 Jan 2015 23:13
URI: http://vuir.vu.edu.au/id/eprint/8541
DOI: 10.1038/ijo.2010.213
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Citations in Scopus: 16 - View on Scopus

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