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Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors : a 12-month randomized controlled weight loss trial

Belski, Regina, Mori, T. A, Puddey, I. B, Sipsas, S, Woodman, R. J, Ackland, T. R, Beilin, L. J, Dove, E. R, Carlyon, N. B, Jayaseena, V and Hodgson, J. M (2011) Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors : a 12-month randomized controlled weight loss trial. International Journal of Obesity, 35. pp. 810-819. ISSN 0307-0565

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Abstract

Background: Regular consumption of diets with increased protein or fibre intakes may benefit body weight and composition and cardiovascular disease risk factors. Lupin flour is a novel food ingredient high in protein and fibre. Objective: To investigate the effects of a lupin-enriched diet, during and following energy restriction, on body weight and composition and cardiovascular disease risk factors in overweight individuals. Design: Participants (n=131) were recruited to a 12-month parallel-design trial. They were randomly assigned to consume lupin-enriched foods or matching high-carbohydrate control foods. All participants underwent 3 months of weight loss, 1 month of weight stabilization and 8 months of weight maintenance. Body weight and composition and cardiovascular disease risk factors were assessed at baseline, 4 and 12 months. Results: Lupin, relative to control, did not significantly influence (mean difference (95% CI)) weight loss at 4 months (0.1 kg (-1.2, 1.4)) and 12 months (-0.6 kg (-2.0, 0.8)), maintenance of weight loss from 4 to 12 months (-0.7 kg (-1.83, 0.48)) or measures of body fat and fat-free mass. Relative to control, 24-h ambulatory systolic ( 1.3mmHg (-2.4, -0.3), P=0.016) and diastolic (-1.0mmHg (-1.9, -0.2), P=0.021) blood pressures were lower at 12 months but not at 4 months; fasting insulin concentrations and homeostasis model assessment (HOMA) scores were significantly lower at 4 months (-1.2mUl–1 (-1.3, -1.1), P=0.004 and -0.6 units (-1.0, -0.19), P=0.004) and 12 months (-1.3 mUl–1 (-1.4, -1.1), P<0.001 and -0.7 units (-1.1, -0.24), P=0.002). Conclusions: A diet higher in protein and fibre derived from lupin-enriched foods does not enhance weight loss or improve the maintenance of weight loss. However, such a diet may provide cardiovascular health benefits in terms of insulin sensitivity and blood pressure.

Item Type: Article
Uncontrolled Keywords: ResPubID19572, lupin, weight loss, blood pressure, insulin, lipids
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1101 Medical Biochemistry and Metabolomics
FOR Classification > 1102 Cardiorespiratory Medicine and Haematology
Depositing User: VUIR
Date Deposited: 22 Dec 2011 00:34
Last Modified: 14 Jan 2015 23:13
URI: http://vuir.vu.edu.au/id/eprint/8541
DOI: 10.1038/ijo.2010.213
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Citations in Scopus: 41 - View on Scopus

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