Research Repository

Heat shock protein 40 (Hsp40) plays a key role in the virus life cycle

Knox, Caroline, Luke, Garry, Blatch, Gregory L and Pesce, Eve-Rachele (2011) Heat shock protein 40 (Hsp40) plays a key role in the virus life cycle. Virus Research, 160 (1-2). pp. 15-24. ISSN 0168-1702

Full text for this resource is not available from the Research Repository.

Abstract

The heat shock proteins (Hsps) are a diverse subset of molecular chaperones that generally promote the proper folding of proteins after translation and also prevent their aggregation during cellular stress. Paradoxically, cellular chaperones might perform important antiviral functions for host cells, yet, at the same time, might be beneficial for virus replication. Among them, Hsp40 is a specialized co-chaperone that has recently received much attention for its crucial role in both constitutive cellular functions and virus pathogenicity. The aim of this review is to raise awareness of its importance in the life cycles of a wide range of viruses.

Item Type: Article
Uncontrolled Keywords: ResPubID22937, J-proteins, Hsp40, chaperone, heat shock
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 1108 Medical Microbiology
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Depositing User: VUIR
Date Deposited: 22 Jul 2012 23:50
Last Modified: 22 Jul 2012 23:50
URI: http://vuir.vu.edu.au/id/eprint/8881
DOI: https://doi.org/10.1016/j.virusres.2011.06.013
ePrint Statistics: View download statistics for this item
Citations in Scopus: 18 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar