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Heat shock protein 40 (Hsp40) plays a key role in the virus life cycle

Knox, Caroline, Luke, Garry, Blatch, Gregory L and Pesce, Eve-Rachele (2011) Heat shock protein 40 (Hsp40) plays a key role in the virus life cycle. Virus Research, 160 (1-2). pp. 15-24. ISSN 0168-1702

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The heat shock proteins (Hsps) are a diverse subset of molecular chaperones that generally promote the proper folding of proteins after translation and also prevent their aggregation during cellular stress. Paradoxically, cellular chaperones might perform important antiviral functions for host cells, yet, at the same time, might be beneficial for virus replication. Among them, Hsp40 is a specialized co-chaperone that has recently received much attention for its crucial role in both constitutive cellular functions and virus pathogenicity. The aim of this review is to raise awareness of its importance in the life cycles of a wide range of viruses.

Item Type: Article
Uncontrolled Keywords: ResPubID22937, J-proteins, Hsp40, chaperone, heat shock
Subjects: Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Current > FOR Classification > 1108 Medical Microbiology
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Depositing User: VUIR
Date Deposited: 22 Jul 2012 23:50
Last Modified: 23 Jul 2020 06:58
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Citations in Scopus: 24 - View on Scopus

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