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Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock

Botha, Melissa, Chiang, Annette, Needham, Patrick, Stephens, Linda L, Hoppe, Heinrich, Kulzer, Simone, Przyborski, Jude M, Lingelbach, Klaus, Wipf, Peter, Brodsky, Jeffrey, Shonhai, Addmore and Blatch, Gregory L (2011) Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock. Cell Stress & Chaperones, 16 (4). pp. 389-401. ISSN 1355-8145

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Abstract

Plasmodium falciparum causes cerebral malaria in humans, and nearly all malaria deaths result from infection by this species. Observations suggest that heat shock proteins play a key role in the management of toxicity conferred by drugs to the parasite, and may augment drug resistance. In addition to their role within the parasite, growing evidence suggests that parasite heat shock proteins are involved in the trafficking of parasite-encoded proteins to the erythrocyte surface, thus playing a key role in the pathogenesis of P. falciparum malaria.

Item Type: Article
Uncontrolled Keywords: ResPubID23311, heat shock protein 70 (Hsp70), heat shock protein 40 (Hsp40), suppressed protein aggregation, Plasmodium falciparum (malaria), immunofluorescence microscopy, ATP hydrolytic rates, molecular chaperone
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 0601 Biochemistry and Cell Biology
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
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Depositing User: VUIR
Date Deposited: 08 Aug 2012 01:53
Last Modified: 23 Mar 2015 01:07
URI: http://vuir.vu.edu.au/id/eprint/9015
DOI: https://doi.org/10.1007/s12192-010-0250-6
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Citations in Scopus: 29 - View on Scopus

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