Research Repository

Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1

Cockburn, Ingrid L and Pesce, Eve-Rachele and Przyborski, Jude M and Davies-Coleman, Michael T and Clark, Peter G. K and Keyzers, Robert A and Stephens, Linda L and Blatch, Gregory L (2011) Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1. Biological Chemistry, 392 (5). pp. 431-438. ISSN 1431-6730 (print) 1437-4316 (online)

Full text for this resource is not available from the Research Repository.

Abstract

Two novel classes of small molecule inhibitors of PfHsp70-1 were identified in this study, one representing a new class of antiplasmodial compound (malonganenones). In addition to demonstrating the validity of PfHsp70-1 as a possible drug target, the compounds will potentially be useful as molecular probes for fundamental studies on Hsp70 chaperone function.

Item Type: Article
Uncontrolled Keywords: ResPubID23312, heat shock proteins, malaria, molecular chaparones, antiplasmodial compound
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 0601 Biochemistry and Cell Biology
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Related URLs:
Depositing User: VUIR
Date Deposited: 08 Aug 2012 01:56
Last Modified: 17 Dec 2014 22:51
URI: http://vuir.vu.edu.au/id/eprint/9016
DOI: 10.1515/BC.2011.040
ePrint Statistics: View download statistics for this item
Citations in Scopus: 7 - View on Scopus

Repository staff only

View Item View Item

Search Google Scholar