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Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin

Mutsvunguma, Lorraine Z, Moetlhoa, Boitumelo, Edkins, Adrienne L, Blatch, Gregory L, Knox, Caroline and Luke, Garry A (2011) Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin. Cell Stress and Chaperones, 16 (5). pp. 505-515. ISSN 1355-8145

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Abstract

This study describes the localisation of Hsps 70 and 90 in BHK-21 cells during Theiler's murine encephalomyelitis virus (TMEV) infection. In addition, the effect of Hsp90 inhibitors novobiocin and geldanamycin on the development of CPE and production of non-structural protein 2C was monitored over a 48 hour period. It is suggested that these chaperones play an important role in the lifecycle of TMEV.

Item Type: Article
Uncontrolled Keywords: ResPubID23314, Theiler's murine encephalomyelitis virus (TMEV), encephalomyelitis virus infection, heat shock proteins, inhibitors, novobiocin, geldanamycin, cell chaperones, picornavirus, Hsp90 inhibitors, cytopathic effect
Subjects: Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
FOR Classification > 0601 Biochemistry and Cell Biology
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Depositing User: VUIR
Date Deposited: 08 Aug 2012 01:57
Last Modified: 24 Mar 2013 23:14
URI: http://vuir.vu.edu.au/id/eprint/9018
DOI: https://doi.org/10.1007/s12192-011-0262-x
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Citations in Scopus: 5 - View on Scopus

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