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Mitochondrial biogenesis related endurance genotype score and sports performance in athletes

Eynon, Nir, Ruiz, Jonatan, Meckel, Yoav, Moran, Maria and Lucia, Alejandro (2011) Mitochondrial biogenesis related endurance genotype score and sports performance in athletes. Mitochondrion, 11 (1). pp. 64-69. ISSN 1567-7249

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We determined the probability of individuals having the ‘optimal’ mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related ‘endurance genotype score’ (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an ‘optimal’ EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P < 0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically ‘optimal’ genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.

Item Type: Article
Uncontrolled Keywords: ResPubID23432, genetics, mitochondria, endurance athletes, sprinters
Subjects: Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
FOR Classification > 1106 Human Movement and Sports Science
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Depositing User: VUIR
Date Deposited: 09 Aug 2012 04:15
Last Modified: 28 Jan 2014 22:55
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Citations in Scopus: 22 - View on Scopus

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