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Mitochondrial biogenesis related endurance genotype score and sports performance in athletes

Eynon, Nir ORCID: 0000-0003-4046-8276, Ruiz, Jonatan, Meckel, Yoav, Moran, Maria and Lucia, Alejandro (2011) Mitochondrial biogenesis related endurance genotype score and sports performance in athletes. Mitochondrion, 11 (1). pp. 64-69. ISSN 1567-7249

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We determined the probability of individuals having the ‘optimal’ mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related ‘endurance genotype score’ (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an ‘optimal’ EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (P < 0.001) in endurance athletes (38.9 ± 17.1) compared with controls (30.6 ± 12.4) or power athletes (29.0 ± 11.2). In summary, although the probability of an individual possessing a theoretically ‘optimal’ genetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis.

Item Type: Article
Uncontrolled Keywords: ResPubID23432, genetics, mitochondria, endurance athletes, sprinters
Subjects: Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Current > FOR Classification > 1106 Human Movement and Sports Science
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Depositing User: VUIR
Date Deposited: 09 Aug 2012 04:15
Last Modified: 28 Jul 2020 06:40
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Citations in Scopus: 28 - View on Scopus

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