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Is there an interaction between BDKRB2−9/+9 and GNB3 C825T polymorphisms and elite athletic performance?

Eynon, Nir and Meckel, Yoav and Alves, Alberto Jorge and Nemet, Dan and Eliakim, Alon (2011) Is there an interaction between BDKRB2−9/+9 and GNB3 C825T polymorphisms and elite athletic performance? Scandinavian Journal of Medicine and Science in Sports, 21 (6). e242-e246. ISSN 0905-7188 (print) 1600-0838 (online)

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Abstract

The −9 deletion allele in the BDKRB2 −9/+9 polymorphism was associated previously with improved endurance performance. We compared the frequency distribution of the BDKRB2 −9/+9 (rs5810761) polymorphism between athletes (n=155) of sports with different demands (endurance runners; n=74 vs sprinters; n=81) as well as between athletes of different competitive levels (elite level; n=46 vs national level; n=109). These results were compared with those of 240 non-athletic healthy individuals. We also tested the influence of the interaction between the BDKRB2 −9/+9 and the GNB3 C825T (rs5443) genotypes in relation to endurance performance. Genotype distribution and allele frequencies were found to be similar in the endurance athlete, sprinter, and control groups (P=0.83 for genotype distribution and P=0.9 for allele frequencies). Similarly, no statistical differences were found between the subgroups of elite-level endurance athletes and national-level endurance athletes, or between elite-level and national-level sprinters (P>0.09 for all comparisons). There was no interaction between BDKRB2 −9/+9 and GNB3 C825T polymorphisms in relation to endurance performance (P=0.16 for interaction effect). In conclusion, the BDKRB2 +9/−9 polymorphism is not associated with endurance performance, at least among Israeli athletes, and the GNB3TT+BDKRB2 −9/−9 “optimal genotype” is not associated with endurance performance.

Item Type: Article
Uncontrolled Keywords: ResPubID23435, genetics, top-level athletes, bradykinin, G-proteins
Subjects: Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
FOR Classification > 1106 Human Movement and Sports Science
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Depositing User: VUIR
Date Deposited: 09 Aug 2012 04:45
Last Modified: 23 Jan 2015 03:32
URI: http://vuir.vu.edu.au/id/eprint/9061
DOI: 10.1111/j.1600-0838.2010.01261.x
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Citations in Scopus: 11 - View on Scopus

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