Physiological variables and mitochondrial-related genotypes of an athlete who excels in both short and long-distance running

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Eynon, Nir ORCID: 0000-0003-4046-8276, Birk, Ruth, Meckel, Yoav, Lucia, Alejandro, Nemet, Dan and Eliakim, Alon (2011) Physiological variables and mitochondrial-related genotypes of an athlete who excels in both short and long-distance running. Mitochondrion, 11 (5). pp. 774-777. ISSN 1567-7249

Abstract

We report the athletic, physiological and mitochondrial-related genomic data of an Israeli endurance runner. He is holding the Israeli record in 10,000, 5000, 1500 and 800 m run, along with being one of the best Israeli 400 m runners. We tested the ACTN3 R577X, and six polymorphisms in the PPARGC1A-NRF-TFAM pathway genes. The case athlete was heterozygous for the ACTN3 R577X variation and had five out of six ‘endurance-oriented’ genotypes, scoring significantly high in endurance ‘optimal’ genotype profile. In conclusion, we suggest that the case athlete is favoured by polygenic profile that is more suitable for mitochondrial biogenesis, regardless of his good phenotypic accomplishments in short-term running events.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/9065
DOI 10.1016/j.mito.2011.05.009
Official URL http://www.sciencedirect.com/science/article/pii/S...
Subjects Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Historical > FOR Classification > 1106 Human Movement and Sports Science
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Keywords ResPubID23439, endurance athlete, genetics, mitochondria
Citations in Scopus 11 - View on Scopus
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