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Physiological variables and mitochondrial-related genotypes of an athlete who excels in both short and long-distance running

Eynon, Nir, Birk, Ruth, Meckel, Yoav, Lucia, Alejandro, Nemet, Dan and Eliakim, Alon (2011) Physiological variables and mitochondrial-related genotypes of an athlete who excels in both short and long-distance running. Mitochondrion, 11 (5). pp. 774-777. ISSN 1567-7249

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Abstract

We report the athletic, physiological and mitochondrial-related genomic data of an Israeli endurance runner. He is holding the Israeli record in 10,000, 5000, 1500 and 800 m run, along with being one of the best Israeli 400 m runners. We tested the ACTN3 R577X, and six polymorphisms in the PPARGC1A-NRF-TFAM pathway genes. The case athlete was heterozygous for the ACTN3 R577X variation and had five out of six ‘endurance-oriented’ genotypes, scoring significantly high in endurance ‘optimal’ genotype profile. In conclusion, we suggest that the case athlete is favoured by polygenic profile that is more suitable for mitochondrial biogenesis, regardless of his good phenotypic accomplishments in short-term running events.

Item Type: Article
Uncontrolled Keywords: ResPubID23439, endurance athlete, genetics, mitochondria
Subjects: Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
FOR Classification > 1106 Human Movement and Sports Science
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Depositing User: VUIR
Date Deposited: 09 Aug 2012 06:07
Last Modified: 09 Nov 2017 04:13
URI: http://vuir.vu.edu.au/id/eprint/9065
DOI: https://doi.org/10.1016/j.mito.2011.05.009
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Citations in Scopus: 7 - View on Scopus

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