Effect of Exercise Training on Insulin Sensitivity, Mitochondria and Computed Tomography Muscle Attenuation in Overweight Women With and Without Polycystic Ovary Syndrome

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Hutchison, Samantha K, Teede, Helena J, Rachon, Dominik, Harrison, Cheryce L, Strauss, Boyd J and Stepto, Nigel (2012) Effect of Exercise Training on Insulin Sensitivity, Mitochondria and Computed Tomography Muscle Attenuation in Overweight Women With and Without Polycystic Ovary Syndrome. Diabetologia, 55 (5). pp. 1424-1434. ISSN 0012-186X (print), 1432-0428 (online)

Abstract

Polycystic ovary syndrome (PCOS) is an insulin resistant (IR) state. Increased skeletal muscle lipid content and impaired mitochondrial biogenesis have been implicated in the pathogenesis of IR. We investigated whether differences in these variables explain the IR of women affected by PCOS and whether improvements in IR with exercise are reflected by changes in these variables.

Item type Article
URI http://vuir.vu.edu.au/id/eprint/9071
Identification Number https://doi.org/10.1007/s00125-011-2442-8
Official URL http://dx.doi.org/10.1007/s00125-011-2442-8
Funders http://purl.org/au-research/grants/nhmrc/606553
Subjects Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Current > FOR Classification > 1106 Human Movement and Sports Science
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Keywords ResPubID23449, ResPubID25389, polycystic ovary syndrome, overweight women, body mass index, BMI, obesity, type 2 diabetes, muscles
Citations in Scopus 30 - View on Scopus
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