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Targeted Inactivation of Kinesin-1 in Pancreatic beta-Cells in Vivo Leads to Insulin Secretory Deficiency

Cui, Ju, Wang, Zai, Cheng, Qianni, Lin, Raozhou, Zhang, Xinmei, Leung, Po sing, Copeland, Neal G, Jenkins, Nancy A, Yao, Kwokming and Huang, Jiandong (2011) Targeted Inactivation of Kinesin-1 in Pancreatic beta-Cells in Vivo Leads to Insulin Secretory Deficiency. Diabetes, 60 (1). pp. 320-330. ISSN 0012-1797

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Abstract

Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression of dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase of glucose-stimulated insulin secretion in β-cells in vitro. In this study, we examined the in vivo physiological role of Kinesin-1 in β-cell development and function.

Item Type: Article
Uncontrolled Keywords: ResPubID23495, kinesin, antisense oligonucleotides, insulin secretion
Subjects: FOR Classification > 0601 Biochemistry and Cell Biology
FOR Classification > 1101 Medical Biochemistry and Metabolomics
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Depositing User: VUIR
Date Deposited: 22 Aug 2012 00:42
Last Modified: 05 Mar 2015 05:49
URI: http://vuir.vu.edu.au/id/eprint/9096
DOI: https://doi.org/10.2337/db09-1078
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Citations in Scopus: 28 - View on Scopus

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