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Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis

Levinger, Pazit and Caldow, Marissa K and Feller, Julian A and Bartlett, John R and Bergman, Neil R and McKenna, Michael J and Cameron-Smith, David and Levinger, Itamar (2011) Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis. Arthritis Care and Research , 63 (12). pp. 1715-1721. ISSN 2151-4658 (online)

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Abstract

Objective Patients with knee osteoarthritis (OA) are characterized by increased muscle inflammation and altered gait. We investigated the association between proinflammatory mediators in the vastus lateralis and physical function and gait in patients with knee OA. Methods Nineteen patients with knee OA underwent gait analysis, assessment of self-reported pain and physical function (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]), and a muscle biopsy that was taken during their knee replacement surgery. Muscle was analyzed for cellular protein inflammatory mediators, interleukin-6, monocyte chemotactic protein 1 (MCP-1), p65 NF-κB, signal transducer and activator of transcription 3 (STAT-3), and JNK-1. Sagittal plane knee function, including early stance knee range of motion (ROM) and knee sagittal plane impulse, was measured using a motion analysis system. Pearson's correlation was used to assess relationships between selected variables. Results Significant positive correlations were found between MCP-1 and self-perceived stiffness, physical function, and the total WOMAC score (P < 0.05). MCP-1 was also negatively correlated with early stance knee ROM (r = −0.52, P = 0.023). Reduced velocity was associated with elevated levels of p65 NF-κB and STAT-3 (P < 0.05). Knee sagittal plane impulse was negatively correlated with JNK-1 (P = 0.02), indicating reduction in knee impulse with an increased level of JNK-1. Conclusion Increased levels of several proinflammatory mediators were correlated with altered knee function during walking as well as greater physical disability and slower gait velocity. Identification of the cellular and molecular mechanisms associated with muscle inflammation is important to better understand the underlying mechanism responsible for altered gait and function in patients with knee OA.

Item Type: Article
Uncontrolled Keywords: ResPubID23907, knee osteoarthritis, muscle inflammation, gait, vastus lateralis, physical function, older adults
Subjects: Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
FOR Classification > 1116 Medical Physiology
SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Depositing User: VUIR
Date Deposited: 19 Jul 2012 23:43
Last Modified: 28 Jan 2015 00:14
URI: http://vuir.vu.edu.au/id/eprint/9251
DOI: 10.1002/acr.20625
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Citations in Scopus: 5 - View on Scopus

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