Plasma nitrite response and arterial reactivity differentiate vascular health and performance

Full text for this resource is not available from the Research Repository.

Allen, Jason, Miller, Elizabeth M, Schwark, Earl, Robbins, Jennifer L, Duscha, Brian D and Annex, Brian H (2009) Plasma nitrite response and arterial reactivity differentiate vascular health and performance. Nitric Oxide: Biology and Chemistry, 20 (4). pp. 231-237. ISSN 1089-8603

Abstract

NO is crucial for endothelial function and vascular health. Plasma nitrite (NO2−) is the main oxidation product of NO and has been shown to reflect changes in eNOS activity. We hypothesized that plasma NO2− response to physical exercise stress along with physiological endothelial function would be reduced with increasing severity of vascular disease. Subject groups were: (a) risk factors but no vascular disease (RF); (b) Type 2 diabetes with no vascular disease (DM); (c) diagnosed peripheral arterial disease (PAD); and (d) DM + PAD. Venous blood was drawn at rest and 10 min following maximal exercise. Plasma samples were analyzed by reductive chemiluminescence. Brachial diameters were imaged prior to, during and following 5 min of forearm occlusion (BAFMD). There were no differences in resting plasma NO2− or BA diameters between groups. The PAD groups had lower age adjusted BAFMD responses (p ⩽ 0.05). Within group analysis revealed an increase in NO2− in the RF group (+39.3%), no change in the DM (−15.51%), and a decrease in the PAD (−44.20%) and PAD + DM (−39.95%). This was maintained after adjusting for age and VO2peak (p ⩽ 0.05). ΔNO2− and BAFMD were the strongest independent predictors of VO2peak in multivariate linear regression. These findings suggest ΔNO2− discriminates severity of cardiovascular disease risk, is related to endothelial function and predicts exercise capacity.

Dimensions Badge

Altmetric Badge

Item type Article
URI https://vuir.vu.edu.au/id/eprint/25758
DOI 10.1016/j.niox.2009.01.002
Official URL http://www.sciencedirect.com/science/article/pii/S...
Subjects Historical > FOR Classification > 1101 Medical Biochemistry and Metabolomics
Historical > FOR Classification > 1106 Human Movement and Sports Science
Current > Division/Research > College of Sports and Exercise Science
Keywords endothelium, nitric oxide, plasma nitrite, cardiovascular disease, exercise, VO2peak
Citations in Scopus 58 - View on Scopus
Download/View statistics View download statistics for this item

Search Google Scholar

Repository staff login