The molecular pathogenesis of osteosarcoma: A review

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Choong, Peter F. M, Broadhead, Matthew L, Clark, Jonathan C. M, Myers, Damian E and Dass, Crispin R (2011) The molecular pathogenesis of osteosarcoma: A review. Sarcoma, 2011. pp. 1-12. ISSN 1357-714X


Osteosarcoma is the most common primary malignancy of bone. It arises in bone during periods of rapid growth and primarily affects adolescents and young adults. The 5-year survival rate for osteosarcoma is 60%–70%, with no significant improvements in prognosis since the advent of multiagent chemotherapy. Diagnosis, staging, and surgical management of osteosarcoma remain focused on our anatomical understanding of the disease. As our knowledge of the molecular pathogenesis of osteosarcoma expands, potential therapeutic targets are being identified. A comprehensive understanding of these mechanisms is essential if we are to improve the prognosis of patients with osteosarcoma through tumour-targeted therapies. This paper will outline the pathogenic mechanisms of osteosarcoma oncogenesis and progression and will discuss some of the more frontline translational studies performed to date in search of novel, safer, and more targeted drugs for disease management.

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Item type Article
DOI 10.1155/2011/959248
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Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Keywords ResPubID24962, chromosomal syndromes, genetic syndromes, alleles, tumour suppressor genes, transforming growth factor, TGF, transforming growth factor, TGF, growth factor beta proteins, TGF-β, bone morphogenic proteins, BMPs, IGF, insulin-like growth factor, Matrix metalloproteinases, MMPs, tumorigenesis
Citations in Scopus 286 - View on Scopus
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