HLA-A and breast cancer in West Peninsular Malaysia

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Leong, Pooi Pooi, Muhammad, Rohaizak, Ibrahim, Naqiyah, Cheong, Soon Keng and Seow, Heng Fong (2011) HLA-A and breast cancer in West Peninsular Malaysia. Medical Oncology, 28 (1). pp. 51-56. ISSN 1357-0560

Abstract

Breast cancer is the most common malignancy among females in Malaysia. Attempts have been made to investigate the association between breast cancer and human leukocyte antigen (HLA) types. However, data from those previous studies are highly variable. The aim of this study is to investigate the association between HLA-A types and clinicopathological factors in breast cancer. The frequencies of HLA-A type in 59 female patients with infiltrating ductal of the breast were determined by polymerase chain reaction method. HLA-A2/A30 and A2/A31 haplotype (5.1%; P = 0.045) as well as HLA-A30 (5.1%, P = 0.045) and A31 (6.8%; P = 0.020) allele were significant higher in the patients than controls (0%). HLAA24 allele was negatively related to lymph node metastasis (r = -0.316; P = 0.021) whereas, A26 (r = -0.430; P = 0.001) and A36 (r = -0.430; P = 0.001) alleles were negatively correlated to distant metastasis in breast cancer. Negative correlations between HLA-A26/A36 (r = -0.430; P = 0.001), A2/A11 (r = -0.276; P = 0.044), A24/A34 (r = -0.430; P = 0.001) haplotypes and distant metastasis were identified. Interestingly, Her2 expression in breast carcinoma was negatively correlated to A11/24 haplotypes (r = -0.294; P = 0.034) but positively correlated to homozygous HLA-A24 (r = 0.396; P = 0.040). In conclusion, HLA-A2, -A30 and A31 were associated with breast cancer.

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Item type Article
URI https://vuir.vu.edu.au/id/eprint/10446
DOI https://doi.org/10.1007/s12032-009-9414-6
Official URL http://dx.doi.org/10.1007/s12032-009-9414-6
Subjects Historical > Faculty/School/Research Centre/Department > School of Biomedical and Health Sciences
Historical > FOR Classification > 1112 Oncology and Carcinogenesis
Keywords ResPubID25015, HLA-A, breast cancer, metastasis, Her2, nodal metastasis, A31 alleles, anti-cancer therapy, epidermal growth factor receptor, EGFR
Citations in Scopus 2 - View on Scopus
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