Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses

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Alikhan, Maliha A, Jones, Christina, Williams, Timothy, Beckhouse, Anthony, Fletcher, Anne L, Kett, Michelle M, Sakkal, Samy, Samuel, Chrishan S, Ramsay, Rob, Deane, James A, Wells, Christine, Little, Melissa, Hume, David and Ricardo, Sharon D (2011) Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses. American Journal of Pathology, 179 (3). pp. 1243-1256. ISSN 0002-9440

Abstract

Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized as scavengers and agents of the innate and the acquired immune systems. Because of their plasticity, macrophages are endowed with many other essential roles during development and tissue homeostasis. We present evidence that CSF-1 plays an important trophic role in postnatal organ growth and kidney repair. Notably, the injection of CSF-1 postnatally enhanced kidney weight and volume and was associated with increased numbers of tissue macrophages. Moreover, CSF-1 promotes postnatal renal repair in mice after ischemia-reperfusion injury by recruiting and influencing macrophages toward a reparative state. CSF-1 treatment rapidly accelerated renal repair with tubular epithelial cell replacement, attenuation of interstitial fibrosis, and functional recovery. Analysis of macrophages from CSF-1-treated kidneys showed increased expression of insulin-like growth factor-1 and anti-inflammatory genes that are known CSF-1 targets. Taken together, these data suggest that CSF-1 is important in kidney growth and the promotion of endogenous repair and resolution of inflammatory injury.

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Additional Information

At head of title: Cell Injury, Repair, Aging, and Apoptosis

Item type Article
URI https://vuir.vu.edu.au/id/eprint/10470
DOI https://doi.org/10.1016/j.ajpath.2011.05.037
Subjects Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Historical > FOR Classification > 1199 Other Medical and Health Sciences
Historical > SEO Classification > 970111 Expanding Knowledge in the Medical and Health Sciences
Keywords ResPubID25070, murine kidney, colony-stimulating factor, CSF, macrophages, postnatal organ growth, renal disease, immune effectors, cell-surface tyrosine kinase receptor, CSF-1R, progenitors, urokinase plasminogen activator, collagen content, ageing
Citations in Scopus 114 - View on Scopus
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