The effect of long-term beta-adrenergic receptor blockade on the oxygen delivery and extraction relationship in patients with coronary artery disease

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Eynon, Nir ORCID: 0000-0003-4046-8276, Sagiv, Moran, Amir, Offer, Ben-Sira, David, Goldhammer, Ehud and Amir, Ruthie (2008) The effect of long-term beta-adrenergic receptor blockade on the oxygen delivery and extraction relationship in patients with coronary artery disease. Journal of Cardiopulmonary Rehabilitation and Prevention, 28 (3). pp. 189-194. ISSN 1932-7501

Abstract

PURPOSE: We evaluated the effects of long-term beta-blocker treatment on the balance between oxygen delivery and extraction at peak oxygen uptake (VO2) and at target heart rate training (anaerobic threshold). METHODS: Fifteen patients with coronary artery disease performed paired peak cardiopulmonary and submaximal exercise tests on a cycle ergometer with and without atenolol treatment. Thirty minutes following the submaximal tests, participants pedaled 10 minutes at a workload corresponding to that of the anaerobic threshold attained. Arterial oxygen was defined from echocardiography and venous oxygen content. CONCLUSIONS: Results demonstrate that atenolol treatment in patients with coronary artery disease does not alter VO2 and workload at the anaerobic threshold and peak exercise because of an increase in oxygen extraction and stroke volume in the face of reduced heart rate. These findings indicate that with long-term beta-adrenergic receptor blockade, there is interplay between oxygen delivery and extraction, suggesting a link between cardiac hemodynamic responses and skeletal muscle metabolic adaptations.

Additional Information

May/June issue

Item type Article
URI https://vuir.vu.edu.au/id/eprint/10491
Subjects Current > FOR Classification > 1102 Cardiorespiratory Medicine and Haematology
Current > FOR Classification > 1106 Human Movement and Sports Science
Historical > Faculty/School/Research Centre/Department > Institute of Sport, Exercise and Active Living (ISEAL)
Keywords ResPubID25127, cardiac output, Fick equation, heart rate, oxygen extraction, stroke volume, coronary artery disease, CAD, drug therapy, blood pressure medicines
Citations in Scopus 15 - View on Scopus
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